Hi Flavio, I know this is an old post, but I am just doing the same tests and have found that to make an ePub that works on both the Mac OS and on a Samsung tablet (that's all I have to test on for Android) is actually quite easy. I am working on a mac, but I don't think that should make any difference.
I used the export setting:
ePub3>All Pages>EPUB File
and found that this one export worked on all the devices. I didn't need to export separately (using ePub3>All Pages>iBooks) for it to work in iBooks on all Apple Devices and computers.
For the Android version on my Samsung tablet, I found that it works best in the Kobo App. It works in the Gitden App too but is annoying as the chrome constantly pops up (ie top menu and page thumbnails) when you touch a button and this doesn't happen in the Kobo App. It would be good to find a way to stop this happening, perhaps there is some CSS than can be written to stop it, but I'm not a coder.
This same export also works perfectly in the Readium for Chrome App in Windows on a PC.
My ePUB has interactive buttons, but no other animation or read aloud etc.
I hope this is helpful for others as there doesn't seem to be much help information on this subject, which I consider the most important reason we are buying the software.